To investigate the mechanisms underlying 15(S)-HETE-induced angiogenesis, we have studied the role of the small GTPase, Rac1.We find that 15(S)-HETE activated Rac1 in human retinal microvascular endothelial cells (HRMVEC) in a time-dependent manner.Blockade of Rac1 by adenovirus-mediated expression of its dominant negative mutant suppressed HRMVEC
Drug resistance is one of the main hurdles for the successful treatment of breast Ear Treatments cancer.The synchronous targeting of apoptosis resistance and survival signal transduction pathways may be a promising approach to overcome drug resistance.In this study, we determined that evodiamine (EVO), a major constituent of the Chinese herbal medi
It is generally suggested that human milk alone might not be enough to meet the nutritional requirements of very preterm infants, necessitating the use of nutritional fortification.The composition of human bottle milk varies among individuals and changes over time, challenging the assumption that protein content and energy density remain constant d
The fear of embarrassment and humiliation is the central element of social anxiety.This frequent condition is associated with cognitive biases indicating increased sensitivity to signals of social threat, which are assumed to play a causal role in the maintenance of social anxiety.Here, we employed laughter, a potent medium for the expression of ac